Dillon Corvino Ph.D
Immunologist who dabbles in bioinformatics
I’m an Australian born and raised, graduated with my Ph.D. in 2019 with a thesis in tumour immunology.
In 2020, I moved to the Institut für Experimentelle Onkologie at the Universitätsklinikum Bonn, Germany, headed by Prof. Michael Hölzel. Here, I will continue my work in understanding anti-tumour NK cell immunology.
I am self taught in bioinformatics and have a keen interest in understanding fundamental processes of immune cells.
Follow me on twitter or message me if you are interested in collaboration or any of my work.
The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and promotes anti-tumor immunity in pre-clinical models. Here, we examined the role of CD226 in the function of tumor-infiltrating lymphocytes (TILs) and resistance to immunotherapy. In murine tumors, a large proportion of CD8+ TILs had decreased surface expression of CD226 and exhibited features of dysfunction, whereas CD226hi TILs were highly functional. This correlation was seen also in TILs isolated from HNSCC patients. ... Mechanistically, tumor-derived CD155, ... initiated phosphorylation of Y319 by Src kinases, thereby enabling ubiquitination of CD226 by CBL-B, internalization, and proteasomal degradation.
CD4+ T cells are critical for control of intracellular parasites such as Leishmania donovani. Kumar et al. show that type I interferons (IFNs) suppress Th1 cells and promote IL-10-producing CD4+ T cells during visceral leishmaniasis (VL). Thus, manipulation of type I IFN signaling may improve disease outcome in VL patients.
Cell Reports 2020
We used high-throughput T cell receptor Vb sequencing and T cell functional profiling to delineate the impact of ACT on T cell repertoire remodeling in the context of pretherapy immunity and ACT products.
Here, we show that Natural Killer Cell Granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4+ and CD8+ T cells played influential roles in promoting inflammation during visceral leishmaniasis and malaria, two important parasitic diseases. Additionally, NKG7 expressed by NK cells was critical for controlling cancer initiation, growth and metastasis.
Nature Immunology 2020
These observations provide an important platform for the future development of immune monitoring and adoptive T-cell therapy strategies for BKV-associated diseases in transplant recipients, which may also be exploited for similar therapeutic value in JCV-associated clinical complications.