Postdoctoral Researcher · University Hospital Bonn

Dillon Corvino, PhD

T cell & NK cell biology  ·  Immuno-oncology  ·  Single-cell multi-omics

Immunologist with 6+ years of postdoctoral experience across tumour immunology, viral immunity, and translational immuno-oncology. I combine wet-lab expertise in human primary tissue and genetic engineering with independent end-to-end single-cell and spatial multi-omics analysis.

My focus is understanding cytotoxic lymphocyte biology and advancing cell therapy strategies from discovery through publication.

Open to industry roles in immuno-oncology and cell therapy across the EU and Australia

Dillon Corvino
970
Citations
15
h-index
6+
Yrs postdoc
€110k
Funding (PI)
Location Bonn, Germany · EU work authorisation
Institution Abdullah Lab, University Hospital Bonn
01

Research

Cytotoxic lymphocyte biology

NK cell plasticity and dysfunction in the tumour microenvironment. CD8 T cell state transitions, type I IFN-driven dysfunction, and unconventional T cell subsets in anti-viral and anti-tumour immunity.

Single-cell & spatial multi-omics

Independent end-to-end pipelines across scRNA-seq, CITE-seq, scATAC-seq, and scTCR-seq on HPC. Spatial transcriptomics and high-multiplex imaging for tissue-resolved characterisation of immune niches.

Cell engineering & therapy

CRISPR knock-out, knock-in, and overexpression in primary human NK and CD8 T cells. CAR-NK and CAR-T cell engineering with proof-of-concept data in preclinical models.

Translational immunology

Reverse translational approaches linking clinical immune phenotypes to mechanistic discovery. Biomarker development from patient tissue through computational analysis to peer-reviewed publication.

Core expertise

Wet Lab
  • Spectral & conventional flow cytometry (40+ colour panels)
  • FACS sorting & tetramer staining
  • CRISPR KO, KI & overexpression in primary NK / CD8 T cells
  • Lentiviral & adenoviral delivery systems
  • Primary human tissue processing (tumour, PBMC, healthy tissue)
  • Air-liquid interface organoids & tissue fragment cultures
  • Murine syngeneic & humanised tumour models
  • LCMV acute & chronic infection models
  • Functional assays: cytotoxicity, ICS, degranulation, proliferation
Computational
  • R / tidyverse (primary language)
  • scRNA-seq · CITE-seq · scATAC-seq · scTCR-seq
  • Seurat · Monocle · ArchR
  • Trajectory inference & chromatin state modelling
  • Spatial transcriptomics & high-multiplex imaging analysis
  • Bulk RNA-seq & DNA-seq
  • HPC pipelines with Nextflow & Singularity
  • GitHub version control & reproducible workflows
  • Scientific visualisation (ggplot2, Adobe Illustrator)
Leadership
  • Independent research programme ownership
  • Full hiring cycle: 3 PhDs & 2 research technicians
  • Scientific mentorship of 10+ PhD, MSc & BSc students
  • PI on €100k BMBF GO-Bio Initial grant
  • International collaboration across 4 continents
  • Manuscript lead & co-author on 20+ publications
  • Peer reviewer: Nature Comms, Immunity, Cancer Immunol Res
02

Publications

Full list on Google Scholar  ·  ORCID 0000-0003-0683-1369  ·  970 citations  ·  h-index 15

2025

Corvino D, Batstone M, Hughes BGM, Kempchen T, Ng SS, Salim N, et al.

Type I Interferon Drives a Cellular State Inert to TCR-Stimulation and Could Impede Effective T-Cell Differentiation in Cancer

European Journal of Immunology, 2025

DOI ↗

Turiello R, Ng SS, Tan E, … Corvino D

NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment

European Journal of Immunology, 2025

DOI ↗
2024

Giordano FA, Layer JP, … Corvino D, et al.

L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial

Nature Communications, 2024

DOI ↗

Hosni S, Kilian V, Klümper N, … Corvino D, et al.

Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma

Cancer Research, 2024

DOI ↗

Casey M, Lee C, Kwok WY, … Corvino D, et al.

Regulatory T cells hamper the efficacy of T-cell-engaging bispecific antibody therapy

Haematologica, 2024

DOI ↗
2023

Corvino D, Rommel D, Schneppenheim F, Bald T

Stressed out: NKp46 binds ecto-calreticulin

Immunology and Cell Biology, 2023

DOI ↗

Wang Y, De Labastida Rivera F, … Corvino D, et al.

STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria

Journal of Clinical Investigation, 2023

DOI ↗
2022

Corvino D, Kumar A, Bald T

Plasticity of NK cells in Cancer

Frontiers in Immunology, 2022

DOI ↗

Li X-Y, Corvino D, Nowlan B, et al.

NKG7 Is Required for Optimal Antitumor T-cell Immunity

Cancer Immunology Research, 2022

DOI ↗
2020

Braun M, … Corvino D, … Bald T

CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells

Immunity, 2020

DOI ↗

Ng SS, … Corvino D, … Engwerda CR

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Nature Immunology, 2020

DOI ↗
2019

Smith C, Corvino D, Beagley L, et al.

T cell repertoire remodeling following post-transplant T cell therapy coincides with clinical response

Journal of Clinical Investigation, 2019

DOI ↗
03

Contact

Open to discussing collaborations, translational research opportunities, and industry roles in immuno-oncology, cell therapy, and computational biology — across the EU and Australia.

Location Bonn, Germany · EU work authorisation
Institution University Hospital Bonn — Abdullah Lab